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As per available reports about 43 Relevant Journals, 54 Conferences, 16 Workshops are presently dedicated exclusively to Genotoxicity and about 417 articles are being published on Genotoxicity.
Genotoxicity describes the property of chemical agents that damages the genetic information within a cell causing a spontaneous phenomenon mutation, which sometimes may lead to cancer instead all mutagens are genotoxic, while, not all genotoxic substances are mutagenic. Genotoxins are a broader category of substances that induce changes to the structure or number of genes via chemical interaction with DNA and/or non-DNA targets this alteration can have direct or indirect effects on the DNA: the induction of mutations, mistimed event activation, and direct DNA damage leading to mutations.
Genotoxicity describes the property of chemical agents that damages the genetic information within a cell causing a spontaneous phenomenon mutation, which sometimes may lead to cancer instead all mutagens are genotoxic, while, not all genotoxic substances are mutagenic. Genotoxins are a broader category of substances that induce changes to the structure or number of genes via chemical interaction with DNA and/or non-DNA targets this alteration can have direct or indirect effects on the DNA: the induction of mutations, mistimed event activation, and direct DNA damage leading to mutations. The permanent, heritable changes can affect either somatic cells of the organism or germ cells to be passed on to future generations. Germ cell mutagens/genotoxins are substances that cause heritable (passed on to progeny) changes in the genetic material Cells prevent expression of the genotoxic mutation by either DNA repair or apoptosis; however, the damage may not always be fixed leading to mutagenesis. The classification of germ cell mutagenicity is hazard based, taking into account a chemical’s intrinsic ability to induce genotoxicity in germ cells, and is not meant for Quantitative risk assessment.
To assay for genotoxic molecules, researchers assay for DNA damage in cells exposed to the toxic substrates. This DNA damage can be in the form of single- and double-strand breaks, loss of excision repair, cross-linking, alkali-labile sites, point mutations, and structural and numerical chromosomal aberrations.
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MARKET ANALYSIS:
The global chemical industry is expected to grow from $4 trillion to $5.3 trillion by 2020. According to a 2011 report from Pike Research, Green Chemistry represents a market opportunity that will grow dramatically from $2.8 billion in 2011 to $98.5 billion by 2020. The same report also estimates that Green Chemistry is forecast to save industry $65.5 billion by 2020. a part of the $5.3 trillion US chemical industry.
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This page was last updated on November 22, 2024
