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As per available reports about 43 Relevant Journals, 43 Conferences, 10 Workshops are presently dedicated exclusively to Vesicular Drug Delivery and about 148 articles are being published on vesicular drug delivery.
Vesicular drug delivery system can be defined as highly ordered assemblies consisting of one or more concentric bilayers formed as a result of self-assembling of amphiphilic building blocks in presence of water. Vesicular drug delivery systems are particularly important for targeted delivery of drugs because of their ability to localize the activity of drug at the site or organ of action thereby lowering its concentration at the other sites in body. Vesicular drug delivery system sustains drug action at a predetermined rate, relatively constant (zero order kinetics), efficient drug level in the body, and simultaneously minimizes the undesirable side effects. It can also localize drug action in the diseased tissue or organ by targeted drug delivery using carriers or chemical derivatization.
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Scope and Importance:
The approaches like provesicular drug delivery, coating of vesicles, layerosomes, ufasomes system etc. have also been developed which have better stabilities in comparison to simple vesicular drug delivery systems. In recent years, the intravesical route has also been exploited either as an adjunct to an oral regimen or as a second-line treatment for Neurogenic bladder. The development of liposomes that can be administered systemically and exhibit targeted and fusogenic properties appears to be increasingly within our grasp. Further in future by combining various other strategies, vesicular system will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, gene and genetic materials safely targeted.
Vesicular drug delivery system can be defined as highly ordered assemblies consisting of one or more concentric bilayers formed as a result of self-assembling of amphiphilic building blocks in presence of water. Vesicular drug delivery systems are particularly important for targeted delivery of drugs because of their ability to localize the activity of drug at the site or organ of action thereby lowering its concentration at the other sites in body. Vesicular drug delivery system sustains drug action at a predetermined rate, relatively constant (zero order kinetics), efficient drug level in the body, and simultaneously minimizes the undesirable side effects. It can also localize drug action in the diseased tissue or organ by targeted drug delivery using carriers or chemical derivatization. Different types of pharmaceutical carriers such as polymeric micelles, particulate systems, and macro- and micromolecules are presented in the form of novel drug delivery system for targeted delivery of drugs. Particulate type carrier also known as colloidal carrier system, includes lipid particles, micro- and nanoparticles, micro- and nanospheres, polymeric micelles and vesicular systems like liposomes, sphingosomes, niosomes, transfersomes, aquasomes, ufasomes, and so forth. Advantages of advanced drug delivery systems over traditional systems are more convenient routes of administration, greater efficacy and duration of drug activity, decreased dosing frequency, improved targeting, as well as reductions in toxic metabolites.
Market Analysis:
The global market for advanced drug delivery systems was valued at $151.3 billion in 2013. This market is forecasted to reach nearly $173.8 billion in 2018, registering a 5-year compound annual growth rate (CAGR) of 2.8%.
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This page was last updated on November 5, 2024
