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As per available reports about 50 Conferences, 91 Workshops and 57 relevant Journals are presently dedicated exclusively to Drug Monitoring and about 13 articles are being published on Drug Monitoring.
TDM is based on the principle that for some drugs there is a close relationship between the plasma level of the drug and its clinical effect. If such a relationship does not exit TDM is of little value. Like any diagnostic test, the measurement of plasma level is justified only when the information provided is of potential therapeutic benefit. The clinical value of plasma level monitoring depends on how precisely the treatment outcome can be defined. When therapeutic outcome can be objectively and replicably quantified, such as during antithrombotic therapy with coumarin derivatives, little additional information is gained by plasma levels. On the other hand when a precise therapeutic and point is difficult to define, monitoring of drug levels may be of considerable therapeutic assistance.
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Scope and Importance:
TDM data provides the clinician with greater insight into the factors determining the patients response to drug therapy. For example when a patient fails to respond to a usual therapeutic dose, measurement of plasma level can help to distinguish a noncompliant patient and a patient who is a true non-responder. TDM also provides useful information regarding individual variations in drug utilization patterns and alteration in drug utilization as a consequence of altered physiological state or disease process.
Therapeutic drug monitoring (TDM) is a division of clinical pharmacology that specializes in the monitoring of medication concentrations in blood. Its main focus is on drugs that can easily be under- or overdosed, that is drugs with a narrow therapeutic range. The selection of drugs for therapeutic drug monitoring is important as the concentrations of many drugs are not clearly related to their effects. Drug monitoring aims to enhance drug efficacy, reduce toxicity or assist with diagnosis. A drug should satisfy certain criteria to be suitable for therapeutic drug monitoring.
Examples include:
• Narrow therapeutic index
• Significant pharmacokinetic variability
• A reasonable relationship between plasma concentrations and clinical effects
• Established target concentration range
• Availability of cost-effective drug assay
Drug monitoring can also be used to detect toxicity, so therapeutic drug monitoring can enhance patient management and improve clinical outcomes. Careful selection of drugs to be monitored should occur. Regular monitoring of many drugs is not required in a clinically stable patient.
Market Analysis:
Therapeutic drug monitoring (TDM) will spike to $2.69 billion by 2019. Therapeutic drug monitoring can be categorized into seven main modalities: antiepileptics, antiarrhythmics, antibiotics, antineoplastics, bronchodilators, immunosuppressives and HIV/AIDS drugs. The global therapeutic drug monitoring market is dominated by eight major suppliers that account for a combined 88.3% of the global market. The U.S. market is expected to grow to $1.84 billion by 2019 at a CAGR of 12.6%.
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This page was last updated on November 25, 2024
