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As per available reports about 3 Conference Proceedings, 9 relevant journals , 16 Conferences , 4 National symposiums are presently dedicated exclusively to Molecular Systems Biology and about 2 articles which are hosed by OMICS International.
Molecular Systems Biology is an open-access peer-reviewed scientific journal publishing research within systems biology at the molecular level, including genomics, proteomics, metabolomics, microbial systems, the integration of cell signaling and regulatory networks, and synthetic biology. The longâ€term goal of biomedical research has always been the complete understanding of biological systems. In the last century, reductionist approaches proved immensely powerful in elucidating many biochemical, genetic, and molecular mechanisms. In this century, we are entering a more synthetic phase in which we will accomplish the goal of completely understanding biological systems in their incredible living complexity. This understanding will be expressed in a number of models, ranging from traditional biological understanding (where individuals construct models in their heads) to formal mathematical models. In any case, reaching a complete understanding requires an unprecedented standardization and completeness of data, greatly improved methods of accessing and linking information, and improved techniques and approaches for mathematical modeling.
Scope and Importance
The cell establishes heritable patterns of active and silenced chromatin via interacting factors that set, remove, and read epigenetic marks. To understand how the underlying networks operate, we have dissected transcriptional silencing in pericentric heterochromatin (PCH) of mouse fibroblasts. We assembled a quantitative map for the abundance and interactions of 16 factors related to PCH in living cells and found that stably bound complexes of the histone methyltransferase SUV39H1/2 demarcate the PCH state. From the experimental data, we developed a predictive mathematical model that explains how chromatin-bound SUV39H1/2 complexes act as nucleation sites and propagate a spatially confined PCH domain with elevated histone H3 lysine 9 trimethylation levels via chromatin dynamics. This "nucleation and looping" mechanism is particularly robust toward transient perturbations and stably maintains the PCH state. These features make it an attractive model for establishing functional epigenetic domains throughout the genome based on the localized immobilization of chromatin-modifying enzymes. Over the last decade, the field of cancer metabolomics has mainly focused on studying the role of tumorigenic metabolic rewiring in supporting cancer proliferation. Here, we perform the first genome-scale computational study of the metabolic underpinnings of cancer migration.
Computational biology can be defined as the application of mathematical modeling, theoretical methods and computer aided simulation for the study of behavioral, social and biological systems. Systems Biology is the computational and mathematical modeling of complex biological systems. Computational Biology has become an important field where you apply concepts of various basic disciplines like applied mathematics, computer science, statistics, animation, biophysics, biochemistry, genomics, genetics, bioinformatics, anatomy, ecology, neuroscience and visualization. This includes the use of biological data to construct relationship models and algorithms among different biological systems to analyze differences and similarities.
We build genome-scale metabolic models of the NCI-60 cell lines that capture the Warburg effect (aerobic glycolysis) typically occurring in cancer cells. The extent of the Warburg effect in each of these cell line models is quantified by the ratio of glycolytic to oxidative ATP flux (AFR), which is found to be highly positively associated with cancer cell migration. We hence predicted that targeting genes that mitigate the Warburg effect by reducing the AFR may specifically inhibit cancer migration. By testing the anti-migratory effects of silencing such 17 top predicted genes in four breast and lung cancer cell lines, we find that up to 13 of these novel predictions significantly attenuate cell migration either in all or one cell line only, while having almost no effect on cell proliferation. Furthermore, in accordance with the predictions, a significant reduction is observed in the ratio between experimentally measured ECAR and OCR levels following these perturbations. Inhibiting anti-migratory targets is a promising future avenue in treating cancer since it may decrease cytotoxic-related side effects that plague current anti-proliferative treatments. Furthermore, it may reduce cytotoxic-related clonal selection of more aggressive cancer cells and the likelihood of emerging resistance.
Market Analysis
In 2013 of global revenue of computational biology North America was obtained 58.0% revenue. For cellular and biological simulation applications computational genomics dominated for over 47% of global revenue. According to the Grand View Research, Inc. US $4,285.1 million growth in computational biology global market with CAGR of 21.1% by 2020.
OMICS International Organizes 1000+ Global Events Every Year across USA, Europe & Asia with support from 1000 more scientific societies Open access journals which contains over 100000 eminent personalities, reputed scientists as editorial board and organizing committee members. The conference series website will provide you list and details about the conference organize worldwide.
List of Best International Conferences
1. 5th Computational Systems Biology Conference
August 22-23, 2016 Philadelphia, USA
2. 2nd Synthetic Biology Conference
August 15-17, 2016 London, United Kingdom
3. 6th Genomics & Pharmacogenomics Conference
September 22-24, 2016 Berlin, Germany
4. 4th Integrative Biology Conference
July 18-20, 2016 Berlin, Germany
5. 2nd Clinical Case Reports
April 18-20, 2016 Dubai, UAE
6. 5th Metabolomics Conference
May 16-18, 2016 Osaka, Japan
7. Protein Engineering Conference
November 14-16, 2016, Atlanta, USA
8. 6th Proteomics Conference
March 29-30, 2016 Atlanta, USA
9. 2nd Therapeutic Drug Monitoring and Toxicogenomics Conference
June 09-10, 2016 Dallas, USA
10. 2nd Retroviruses & Novel Drugs Conference
June 30-July 01, 2016 Cape Town, South Africa
11. Drug Delivery Summit
August 17-19, 2015 Houston, USA
12. Drug Formulation & Bioavailability Congress
June 06-08, 2016 Beijing, China
13. Healthcare Expo
October 05-07, 2015 New Delhi, India
14. 5th Occupational Health & Safety Conference
June 06-07, 2016 Dallas, USA
15. 8th Healthcare Summit
November 09-11, 2015 Dubai, UAE
16. 4th Nursing & Healthcare Conference
October 05-07, 2015 San Francisco, USA
17. 27th International Conference on Computational Intelligence
18. 21st EMBO:EMBL Symposium: Enabling Technologies for Eukaryotic Synthetic Biology
19. 14th 5th International Conference on Proteomics and Bioinformatics
20. 1st EMBL Conference: Cancer Genomics Heidelberg
21. Biological Cell Information Processing Workshop UCNC'15
22. 6th International Workshop on Biological Knowledge Discovery and Data Mining
23. The 4th International Workshop on Hybrid Systems Biology
• Association for Biology Laboratory Education - ABLE
• International Chemical Biology Society
• American Society of Cell Biology
• Systems Biology and Biomedical Informatics (SBBI) Laboratory
• Sbarro Health Research Organization (SHRO)
• North Carolina Biotechnology Center
• Federation of American Societies FOR Experimental Biology
• American association for cancer research
• Clinical Genetics Society
• American Society for Biochemistry and Molecular Biology
• International Society for Computational Biology: ISCB
• Computational Biology and Bioinformatics Organization
• American Heart Association
• American Society of Cell Biology
• American Society for Biochemistry and Molecular Biology
• The International Society for Systems Biology
• Canadian Society for Systems Biology
• IACSIT Bioinformatics and Biomedical Engineering Society (BBES) • African Society for Bioinformatics and Computational Biology • International Society for Computational Biology (ISCB) • British Society for Genetic Medicine (BSGM) • African Society of Human Genetics (AfSHG) • Human Genome Variation Society (HGSV)
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This page was last updated on December 23, 2024
