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Tumor suppressors
Tumor suppressors are also called as anti-oncogene which protects the gene of the cell from different disease like cancer. Due to the diseased conditions the functions of the cells gets reduced when it combined with other genetic changes.
The loss of these gene leads to formation of the cancer cells by oncogene activation.
Based on the function the tumor suppressors are categories in to many names like care taker genes, landscaper genes, gate keeper gene etc. Information about the tumor suppressors helps in medicinal advances and useful in the study of genetics, molecular genetics, epigenetics, molecular biology etc.
Example: p53
The product of the tumor suppresser gene p53 is a protein of fifty three kilo Daltons (hence the name). (You can notice that the human gene is multifariously selected as P53, TP53 ["tumor protein 53"], and TRP53 ["transformation-related protein 53"])
The p53 protein prevents a cell from finishing the cell cycle if
• Its DNA is broken or
• The cell has suffered alternative sorts of injury.
When
• The injury is minor, p53 halts the cell cycle — thence biological process — till the injury is repaired.
• The injury is major and can't be repaired; p53 triggers the cell to kill by cell death.
These functions build p53 a key player in protecting us against cancer; that's, it's a crucial tumor suppresser gene. Quite 1/2 all human respiratory organ, ovarian, and body part cancers harbor p53 mutations and haven't any functioning p53 macromolecule.
Mice are cured of cancer by treating them with a amide that activates production of the p53 macromolecule within the tumor cells. However, there could also be an exchange involved: excess production of the p53 macromolecule ends up in accelerated aging in mice.
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Conferences
Asian Oncology Summit 2014
Venue: Shangri-La Hotel - Kuala Lumpur
Location: Kuala Lumpur, Malaysia
BEGINS: Apr 11, 2014Ends Apr 13, 2014
Clinical Genomics 2014
Venue: Hyatt Regency Boston
Location: Boston, Massachusetts, United States
BEGINS: Jan 28, 2014Ends Jan 30, 2014
Keystone Symposia The Ubiquitin System - From Basic Science to Drug Discovery (A2)
Venue: BIG SKY RESORT
Location: Big Sky, Montana, United States
BEGINS: Jan 07, 2014Ends Jan 12, 2014
Pharmaceutical Nanotechnology Congregation 2013
Venue: Hilton Hotel
Location: London, United Kingdom
BEGINS: Oct 15, 2013Ends Oct 16, 2013
qPCR and Digital PCR Congress
Venue: Hilton Lyon
Location: Lyon, France
BEGINS: Sep 09, 2013 08:00 AMEnds Sep 10, 2013 05:00 PM
Molecular Dx for Cancer Drug Development
Venue: Hyatt Regency Cambridge
Location: Cambridge, Massachusetts, United States
BEGINS: Jun 18, 2013Ends Jun 20, 2013
BIT's 6th Anniversary of World Cancer Congress (WCC-2013)
BEGINS: May 23, 2013 08:30 AMEnds May 25, 2013 05:30 PM
Keystone Symposia Antibodies as Drugs
Venue: Fairmont Hotel Vancouver
Location: Vancouver, British Columbia, Canada
BEGINS: Jan 27, 2013Ends Feb 01, 2013
Dedicated Training Course aOncology Drug Development in Practicea (ODDP)
Venue: Dorint Hotel Amsterdam-Airport
Location: Amsterdam, Namibia
BEGINS: Nov 27, 2012Ends Oct 30, 2012
Strategies for Managing the Rising Costs of Oncology Treatment
BEGINS: Nov 14, 2012 01:00 PM
2nd Annual Next Generation Sequencing Asia Congress 2012
Venue: Novotel Clarke Quay Singapore
Location: Singapore, Singapor
e BEGINS: Oct 01, 2012Ends Oct 02, 2012
2nd Next Generation Sequencing Asia Congress
Venue: Concorde Hotel Singapore
Location: Singapore, Singapore
BEGINS: Oct 01, 2012Ends Oct 02, 2012
Biomarkers 2012
Venue: London Marriott Marble Arch Hotel, London, UK
Location: London
BEGINS: Sep 26, 2012Ends Sep 26, 2012
Molecular Diagnostics World Congress and Exhibition
Venue: Town and Country Resort Hotel
Location: San Diego, California 92108, United States
BEGINS: Sep 25, 2012Ends Sep 26, 2012
The 1st Multidisciplinary Symposium a Molecular oncology from laboratory bench to medicine
Venue: Institute of Molecular Biology and Genetics NAS of Ukraine
Location: Kyiv, Ukraine
BEGINS: Sep 17, 2012Ends Sep 22, 2012
International Conference on Central Nervous System - Drugs Effects Novel Drug Development
Venue: DoubleTree by Hilton
Location: Philadelphia, United States
BEGINS: Sep 05, 2012Ends Sep 07, 2012
13th International Lung Cancer Congress
Venue: Hyatt Regency Huntington Beach
Location: Huntington Beach, California, United States
BEGINS: Jul 19, 2012Ends Jul 22, 2012
Global problems of the state, reproduction and use of natural resources of the planet Earth
Venue: London
Location: London, United Kingdom
BEGINS: Jul 13, 2012Ends Jul 18, 2012
Companies
Bavarian Nordic, Mountain View, CA
Juvaris, Pleasanton, CA
PaxVax, San Diego, CA
MSD, Ireland
Genocea Bioscience, Cambridge, MA
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This page was last updated on November 22, 2024
